老年人静息代谢率的变化：横断面和纵向数据。
Changes in resting metabolic rate in an elderly German population: cross-sectional and longitudinal data.
机构信息
Institute of Nutritional Science, Justus-Liebig-University Goethestrasse 55, D-35390 Giessen, Germany.
出版信息
J Nutr Health Aging. 2010 Mar;14(3):232-6. doi: 10.1007/s12603-010-0055-4.
BACKGROUND/OBJECTIVES: This study investigates age-dependent changes in resting metabolic rate (RMR) considering changes in body composition and fat distribution within the longitudinal study on nutrition and health status in an aging population in Giessen (GISELA), Germany, using three different approaches.
SUBJECTS/METHODS: In approach 1 cross-sectional data from 358 female and 155 male participants of the GISELA study were evaluated (mean age of 67.4 +/- 5.9 and 66.9 +/- 5.2 y, respectively). In approach 2 longitudinal data of 107 female and 55 male subjects who participated over a follow up period of 10 years were analysed. In approach 3 all data obtained at a total of 3033 visits from 363 women and 153 men between 1994 and 2006 were evaluated. The mean duration of follow-up was eight years. RMR was assessed by indirect calorimetry.
RESULTS
Approach 1: RMR correlates significantly negatively with age in women and men. Considering fat free mass, fat mass, and WHR, age proved to be a significant predictor of RMR in both sexes in multiple regression analysis; RMR falls by 11.2 kJ/d and 34.1 kJ/d per year in females and males, respectively. Approach 2: In males but not in females RMR decreases significantly in the course of the follow up. After ten years measured RMR is significantly lower than expected RMR predicted on the basis of body composition and fat distribution in females and males. Deviations correspond to a decline in RMR by 11.4 and 27.5 kJ/d per year independently of changes in body composition and fat distribution. Approach 3: Results of the mixed linear model show that RMR decreases in the course of aging in both women and men; after considering changes in body composition and fat distribution respective decreases were 8.7 and 30.7 kJ/d per year.
CONCLUSIONS
These results indicate that the decline in RMR with advancing age cannot be totally due to changes in body composition.
背景/目的：本研究通过三种不同方法，使用营养与健康状况纵向研究中德国吉森老龄化人群（GISELA）的横断面和纵向数据，探讨了静息代谢率（RMR）随年龄的变化，同时考虑了身体成分和脂肪分布的变化。
受试者/方法：在方法 1 中，评估了 GISELA 研究中 358 名女性和 155 名男性参与者的横断面数据（平均年龄分别为 67.4 +/- 5.9 和 66.9 +/- 5.2 岁）。在方法 2 中，分析了参加为期 10 年随访的 107 名女性和 55 名男性的纵向数据。在方法 3 中，评估了 1994 年至 2006 年期间，363 名女性和 153 名男性共 3033 次就诊时获得的所有数据。平均随访时间为 8 年。RMR 通过间接热量法评估。
结果
方法 1：RMR 与女性和男性的年龄呈显著负相关。在多回归分析中，考虑到去脂体重、脂肪量和腰臀比，年龄是两性 RMR 的显著预测因子；女性和男性的 RMR 每年分别下降 11.2 kJ/d 和 34.1 kJ/d。方法 2：在男性中，但不是在女性中，RMR 在随访过程中显著下降。10 年后，女性和男性的实测 RMR 明显低于基于身体成分和脂肪分布预测的预期 RMR。偏差相当于 RMR 每年下降 11.4 和 27.5 kJ/d，与身体成分和脂肪分布的变化无关。方法 3：混合线性模型的结果表明，女性和男性的 RMR 随年龄增长而下降；在考虑身体成分和脂肪分布变化后，相应的下降分别为 8.7 和 30.7 kJ/d/年。
结论
这些结果表明，RMR 随年龄增长而下降不能完全归因于身体成分的变化。
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