Crişan A, Tudorache V, Mihăicuţă St, Laza Ruxandra
Facultatea de Medicină, Clinica a II-a Boli Infecţioase, Universitatea de Medicină si Farmacie "V. Babeş" Timişoara.
Rev Med Chir Soc Med Nat Iasi. 2009 Jul-Sep;113(3):766-70.
In our country prolonged fever is frequently caused by tuberculosis infection, that is recrudescent. Localized hepatic tuberculosis is a rare clinical form of this specific infection. The authors present the case of a 26 year old man who developed prolonged fever, highly elevated liver enzymes and meningitis syndrome and was admitted to Clinical Hospital of Infectious Diseases and Pneumophtisiology Dr. V. Babeş Timişoara during 24.03 - 16.05.2008. Diagnosis of hepatobiliary tuberculosis, acute bacillary meningitis and miliary tuberculosis were established by clinical, laboratory criteria and sustained by imaging techniques. Dynamics of biological features, diagnostic pitfalls, differential diagnosis difficulties, therapeutic schedules and peculiar aspects of evolution are presented. Liver involvement can be the only manifest form of miliary tuberculosis and when it is associated with prolonged fever obligates to begin quadruple specific therapy, especially in communities where tuberculosis is prevalent. Bacteriological findings are belated and antituberculous therapy can not be started early. Quadruple association of antituberculous drugs with corticotherapy and liver protective medication showed utility in favorable resolving of this case.
在我国,长期发热常由结核感染复发引起。局限性肝结核是这种特定感染的一种罕见临床形式。作者介绍了一例26岁男性病例,该患者出现长期发热、肝酶显著升高和脑膜炎综合征,并于2008年3月24日至5月16日入住蒂米什瓦拉市V. 巴贝斯传染病与肺病临床医院。通过临床、实验室标准及影像学技术确诊为肝胆结核、急性细菌性脑膜炎和粟粒性结核。文中介绍了生物学特征的动态变化、诊断陷阱、鉴别诊断困难、治疗方案及演变的特殊方面。肝脏受累可能是粟粒性结核的唯一表现形式,当与长期发热相关时,尤其在结核病流行的社区,必须开始四联特异性治疗。细菌学检查结果延迟出现,抗结核治疗无法早期开始。抗结核药物与皮质激素治疗及肝脏保护药物的四联联合应用对该病例的良好转归显示出有效性。