Săndulache L, Stanciu C
Institutul de Gastroenterologie si Hepatologie Iaşi, Facultatea de Medicină, Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2009 Oct-Dec;113(4):1056-60.
Hepatic encephalopathy (HE) is a frequent complication of liver cirrhosis, and plasma ammonia plays a pivotal role in its pathogenesis. Helicobacter pylori (H. pylori) urease activity is a potential source of ammonia in the stomach of patients with cirrhosis and may contribute to hyperammonemia in these patients, but conflicting data are available in the literature. The aim of our study was to evaluate the prevalence of H. pylori infection in cirrhotic patients with HE admitted in a tertiary medical center from nord-eastern region of Romania.
seroprevalence of H. pylori infection in cirrhotic patients with HE did not significantly differ from cirrhotic patients without HE (51.61% vs. 48.39%). Clinical and biochemical parameters were almost similar between patients with HE H. pylori-positive and those H. pylori-negative.
the prevalence of H. pylori infection in cirrhotic patients with HE is almost similar to that found in patients with liver cirrhosis without HE. Our results suggest that H. pylori infection is not an independent risk factor for HE in cirrhotic patients.
肝性脑病（HE）是肝硬化常见的并发症，血浆氨在其发病机制中起关键作用。幽门螺杆菌（H. pylori）脲酶活性是肝硬化患者胃内氨的潜在来源，可能导致这些患者出现高氨血症，但文献中的数据存在矛盾。我们研究的目的是评估罗马尼亚东北部一家三级医疗中心收治的肝硬化合并HE患者中幽门螺杆菌感染的患病率。
肝硬化合并HE患者中幽门螺杆菌感染的血清阳性率与无HE的肝硬化患者无显著差异（51.61%对48.39%）。HE合并幽门螺杆菌阳性的患者与幽门螺杆菌阴性的患者临床和生化参数几乎相似。
肝硬化合并HE患者中幽门螺杆菌感染的患病率与无HE的肝硬化患者几乎相似。我们的结果表明，幽门螺杆菌感染不是肝硬化患者发生HE的独立危险因素。
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