Takane K K, Husmann D A, McPhaul M J, Wilson J D
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8857.
Endocrinology. 1991 May;128(5):2234-8. doi: 10.1210/endo-128-5-2234.
The rat phallus grows during sexual maturation as serum androgen concentrations rise to adult levels, and growth ceases when sexual maturity is attained despite the continued presence of adult serum androgen levels. This cessation of growth is correlated temporally with a diminution in the levels of androgen receptor, as detected by assays of ligand binding. To determine whether the change in androgen receptor content occurs in all cells in the tissue, immunohistochemical studies of the penile androgen receptor were performed in rats of different ages. In immature animals and animals castrated prepubertally, the androgen receptor is detected in virtually all cell types, including the corpus cavernosum penis, the small lateral cavernous bodies, the corpus cavernosum urethra, skin, urethra, and os penis. By contrast, in the mature rat penis minimal androgen receptor is evident within the corporal tissue and os, although immunoreactivity remains detectable in the penile skin and urethra. It is concluded that the cessation of androgen-mediated growth correlates with a decrease in androgen receptor levels in the body of the penis.
随着血清雄激素浓度上升至成年水平，大鼠阴茎在性成熟过程中生长，而当达到性成熟时，尽管成年血清雄激素水平持续存在，生长仍会停止。这种生长停止在时间上与雄激素受体水平的降低相关，这是通过配体结合测定检测到的。为了确定雄激素受体含量的变化是否发生在组织中的所有细胞中，对不同年龄的大鼠进行了阴茎雄激素受体的免疫组织化学研究。在未成熟动物和青春期前阉割的动物中，几乎在所有细胞类型中都能检测到雄激素受体，包括阴茎海绵体、小的外侧海绵体、尿道海绵体、皮肤、尿道和阴茎骨。相比之下，在成熟大鼠阴茎中，海绵体组织和阴茎骨内的雄激素受体极少，尽管在阴茎皮肤和尿道中仍可检测到免疫反应性。得出的结论是，雄激素介导的生长停止与阴茎体内雄激素受体水平的降低相关。
