Khubchandani Shaila R, Chitale Arun R, Gowrishankar Swarnalata
Jaslok Hospital & Research Center, Bhatia Hospital, Mumbai, India.
Ultrastruct Pathol. 2010 Apr;34(2):68-72. doi: 10.3109/01913120903506611.
The normal glomerular basement membrane, composed of type IV collagen, plays an important function in the process of filtration. Rarely, type III, type I, or type V collagen is seen in the glomerulus, resulting in three different types of non-immune mediated glomerulopathies recognized thus far. These are characterized by deposition of banded collagen fibers in the glomerulus.
The authors reviewed 4934 kidney biopsies submitted over the past 5 years. Five of these revealed the presence of banded collagen in the glomeruli.
Combined clinical and ultrastructural examination has led to a definitive diagnosis. These diseases exhibit indolent progression and as yet do not have specific treatment.
正常的肾小球基底膜由IV型胶原组成，在滤过过程中发挥重要作用。在肾小球中很少见到III型、I型或V型胶原，由此产生了迄今为止已确认的三种不同类型的非免疫介导性肾小球病。这些疾病的特征是带状胶原纤维在肾小球中沉积。
作者回顾了过去5年提交的4934份肾活检标本。其中5份显示肾小球中存在带状胶原。
临床和超微结构检查相结合已得出明确诊断。这些疾病进展缓慢，目前尚无特异性治疗方法。
