Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Gynecol Endocrinol. 2010 May;26(5):325-32. doi: 10.3109/09513591003632100.
To explore the effects of overweight and obesity on the outcomes of in vitro fertilisation (IVF) in Chinese infertile patients.
A retrospective cohort study was carried out in 2222 normal weight (18.5 <or= BMI < 25), 379 overweight (25 <or= BMI < 30) and 27 obese (BMI >or= 30) women who underwent their first IVF cycles between 2002 and 2008. Cycle characteristics and IVF outcomes were analysed.
Obese women required significantly higher dose of rFSH (3272 IU vs. 2587 IU, p < 0.001) and days of stimulation (11.89 +/- 4.57 vs. 10.42 +/- 2.03, p < 0.001), but exhibited less oocytes retrieved and significantly lower fertilisation rate (54.1% vs. 61.1%, p < 0.001) than normal weight women. Compared with normal weight women, overweight women displayed significantly less oocytes retrieved (12.98 +/- 6.91 vs. 14.49 +/- 7.96, p < 0.001), lower fertilisation rate (60.8 +/- 23.3 vs. 61.1 +/- 23.0, p < 0.001), less cleavaged embryos (7.55 +/- 4.86 vs. 8.67 +/- 5.90, p < 0.001), less high-grade embryos (4.65 +/- 3.96 vs. 5.59 +/- 4.81, p < 0.001) and cryopreserved embryos (4.44 +/- 4.55 vs. 5.49 +/- 5.55, p < 0.001). All parameters of pregnancy outcomes, including pregnancy rate, miscarriage rate and live birth rate, were comparable among three groups.
Overweight and obesity are related with impared ovarian response, and negatively affect the outcomes of IVF.
探讨超重和肥胖对中国不孕患者体外受精（IVF）结局的影响。
对 2002 年至 2008 年间接受首次 IVF 周期的 2222 名正常体重（18.5≤BMI＜25）、379 名超重（25≤BMI＜30）和 27 名肥胖（BMI≥30）女性进行回顾性队列研究。分析了周期特征和 IVF 结局。
肥胖女性需要更高剂量的 rFSH（3272 IU 比 2587 IU，p＜0.001）和更长的刺激天数（11.89±4.57 比 10.42±2.03，p＜0.001），但获得的卵母细胞较少，受精率明显较低（54.1%比 61.1%，p＜0.001）。与正常体重女性相比，超重女性获得的卵母细胞较少（12.98±6.91 比 14.49±7.96，p＜0.001），受精率较低（60.8±23.3 比 61.1±23.0，p＜0.001），卵裂胚胎较少（7.55±4.86 比 8.67±5.90，p＜0.001），优质胚胎较少（4.65±3.96 比 5.59±4.81，p＜0.001），冷冻胚胎较少（4.44±4.55 比 5.49±5.55，p＜0.001）。三组妊娠结局的所有参数，包括妊娠率、流产率和活产率，均无差异。
超重和肥胖与卵巢反应受损有关，并对 IVF 结局产生负面影响。
