Laboratoire de Physiologie Animale, Department of Molecular Biology, Université Libre de Bruxelles, Gosselies, Belgium.
Immunol Rev. 2010 Mar;234(1):317-34. doi: 10.1111/j.0105-2896.2009.00887.x.
Since their discovery in 1973, dendritic cells (DCs) have gained strong interest from immunologists because of their unique capacity to sensitize naive T cells. There is now strong evidence that cells of the dendritic family not only control immunity but also regulate responses to self and non-self, thereby avoiding immunopathology. These two complementary functions are critical to ensure the integrity of the organism in an environment full of antigens. How DCs display these opposite functions is still intriguing. Here, we review the role of DC subsets in the regulation of T-helper responses in vivo.
自 1973 年发现以来，树突状细胞 (DCs) 因其独特的激活幼稚 T 细胞的能力而引起免疫学家的浓厚兴趣。现在有强有力的证据表明，树突状细胞家族的细胞不仅控制免疫，而且还调节对自身和非自身的反应，从而避免免疫病理学。这两个互补的功能对于确保在充满抗原的环境中生物体的完整性至关重要。树突状细胞如何表现出这些相反的功能仍然很吸引人。在这里，我们回顾了 DC 亚群在体内调节辅助性 T 细胞反应中的作用。
