Adachi Mental Clinic, Kitano 7-5-12, Kiyota, Sapporo, Japan.
Br J Psychiatry. 2010 Mar;196(3):212-6. doi: 10.1192/bjp.bp.108.056721.
Age at the first psychotic episode and an interval between the onset of epilepsy and that of psychosis reflect developmental processes of interictal psychosis. However, factors relating to these indices remain unknown.
To identify clinical variables that are associated with the timing of the development of interictal psychosis.
In 285 adults with epilepsy with interictal psychosis, effects of epileptic (epilepsy type), organic (intellectual functioning) and genetic (family history of psychosis) variables on timing of the development of psychosis were examined.
The mean interval between the onset of epilepsy and that of psychosis was 14.4 years. Some psychosis occurred within a few years of the first seizure. Generalised epilepsy, normal intellectual function and a positive family history of psychosis were associated with early onset of psychosis.
Early development of interictal psychosis in people with epilepsy may reflect other individual vulnerabilities to psychosis rather than epilepsy-related damage.
首次精神病发作的年龄和癫痫发作与精神病发作之间的间隔反映了癫痫间期精神病的发展过程。然而，与这些指标相关的因素仍不清楚。
确定与癫痫间期精神病发展时间相关的临床变量。
在 285 名患有癫痫伴癫痫间期精神病的成年人中，研究了癫痫（癫痫类型）、有机（智力功能）和遗传（精神病家族史）变量对精神病发展时间的影响。
癫痫发作与精神病发作之间的平均间隔为 14.4 年。有些精神病发生在首次发作后的几年内。全面性癫痫、智力正常和精神病家族史阳性与精神病的早期发作有关。
癫痫患者癫痫间期精神病的早期发展可能反映了个体对精神病的其他易感性，而不是与癫痫相关的损伤。
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