PRISM-E研究中针对老年抑郁症患者的综合护理的成本效益
Cost-effectiveness of integrated care for elderly depressed patients in the PRISM-E study.
作者信息
Wiley-Exley Elizabeth, Domino Marisa Elena, Maxwell James, Levkoff Sue Ellen
机构信息
Department of Health Policy and Management, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7411, USA.
出版信息
J Ment Health Policy Econ. 2009 Dec;12(4):205-13.
BACKGROUND
One proposed strategy to improve outcomes associated with depression and other behavioral health disorders in primary care settings is to strengthen collaboration between primary care and specialty mental health care through integrated care (IC).
AIMS
We compare the cost-effectiveness of IC in primary care to enhanced specialty referral (ESR) for elders with behavioral health disorders from the Primary Care Research in Substance Abuse and Mental Health study, which was a randomized trial conducted between 2000 and 2002, using a societal perspective.
METHODS
The IC model had a behavioral health professional co-located in the primary care setting, and the primary care provider continued involvement in the mental health/substance abuse care of the patient. The comparison model, enhanced specialty referral (ESR), required referral to a behavioral health provider outside the primary care setting, and the behavioral health provider had primary responsibility for the mental health/substance abuse needs of the patient. Costs and clinical outcomes for 840 elders with depression were analyzed using incremental cost-effectiveness ratios, the net benefits framework, cost-effectiveness planes, and acceptability curves. Outcomes were measured by the Center for Epidemiologic Studies Depression Scale (CES-D) and converted to depression-free days and Quality Adjusted Life Years (QALY). A variation on depression free days was proposed as an improvement on current methods. Separate analyses were conducted for Veteran's Affairs (n=365; n=175 in IC and n=190 in ESR) and non-Veteran's Affairs (n=475; n=242 in IC and n=233 in ESR) settings.
RESULTS
ESR participants in the non-VA sample exhibited lower average CES-D scores (i.e., an improvement in depressive symptoms) than did IC participants (beta = 2.8, p < 0.01), no such difference was noted in the VA sample (p > 0.05). Mean costs were $D6,338 for VA IC participants; $7,007 for VA ESR participants; $3,657 for non-VA IC participants; and $3,673 for non-VA ESR participants. Although the cost-effectiveness planes suggest some uncertainty about the cost-effectiveness of the intervention, more than 75% of the bootstrap draws were considered cost-effective due to a decrease in total costs for IC in the full Veteran's Affairs sample.
DISCUSSION
The findings indicate that IC is likely to be a cost-effective intervention in contrast with ESR in the Veteran's Affairs setting. In the non-Veteran's Affairs settings, IC is not a more cost-effective intervention in comparison with ESR. In the VA setting, the greater clinical improvement associated with IC coupled with the variation in costs and outcomes were such that IC was determined to be more cost-effective than ESR with a probability of 73-80%. Among non-VA participants, the lower clinical outcomes combined with no discernable differences in costs translated with a low probability that IC was more cost-effective than ESR, at any of the estimated values of clinical improvements. This suggests the importance of clinical setting in determining the clinical and cost effectiveness of IC for mental health.
LIMITATIONS
Our analyses were restricted to a six-month period, based on self-report, and did not include societal costs related to lost productivity and future costs.
IMPLICATIONS
These results suggest that general integration has its advantages and, when such integration exists, further integrating behavioral health care into primary care might be considered as one way to improve depression in elders. The finding that ESR may be cost effective in some settings is also policy relevant. Further research is needed to analyze the components of the costs of ESR in non-VA settings and the effectiveness of IC in VA settings.
背景
在初级保健环境中,一种被提议的改善与抑郁症及其他行为健康障碍相关结局的策略是,通过综合护理(IC)加强初级保健与专科心理健康护理之间的协作。
目的
我们从社会角度比较了初级保健中综合护理(IC)与强化专科转诊(ESR)对患有行为健康障碍老年人的成本效益,该比较基于2000年至2002年进行的药物滥用和心理健康初级保健研究中的一项随机试验。
方法
综合护理(IC)模式有一名行为健康专业人员与初级保健机构同处一地,初级保健提供者持续参与患者的心理健康/药物滥用护理。对照模式,即强化专科转诊(ESR),要求转诊至初级保健机构以外的行为健康提供者,该行为健康提供者对患者的心理健康/药物滥用需求负主要责任。使用增量成本效益比、净效益框架、成本效益平面和可接受性曲线分析了840名抑郁症老年人的成本和临床结局。结局通过流行病学研究中心抑郁量表(CES-D)进行测量,并转换为无抑郁天数和质量调整生命年(QALY)。提出了一种无抑郁天数的变体作为对当前方法的改进。对退伍军人事务部(n = 365;综合护理组175人,强化专科转诊组190人)和非退伍军人事务部(n = 475;综合护理组242人,强化专科转诊组233人)的情况分别进行了分析。
结果
非退伍军人事务部样本中的强化专科转诊(ESR)参与者的平均CES-D得分低于综合护理(IC)参与者(即抑郁症状有所改善)(β = 2.8,p < 0.01),而在退伍军人事务部样本中未发现此类差异(p > 0.05)。退伍军人事务部综合护理(IC)参与者的平均成本为6338美元;退伍军人事务部强化专科转诊(ESR)参与者为7007美元;非退伍军人事务部综合护理(IC)参与者为3657美元;非退伍军人事务部强化专科转诊(ESR)参与者为3673美元。尽管成本效益平面表明干预措施的成本效益存在一定不确定性,但由于整个退伍军人事务部样本中综合护理(IC)的总成本有所下降,超过75%的自抽样被认为具有成本效益。
讨论
研究结果表明,与退伍军人事务部环境中的强化专科转诊(ESR)相比,综合护理(IC)可能是一种具有成本效益的干预措施。在非退伍军人事务部环境中,与强化专科转诊(ESR)相比,综合护理(IC)并非更具成本效益的干预措施。在退伍军人事务部环境中,综合护理(IC)带来的更大临床改善以及成本和结局的差异使得综合护理(IC)被确定比强化专科转诊(ESR)更具成本效益,概率为73 - 80%。在非退伍军人事务部参与者中,较低的临床结局加上成本上无明显差异意味着在任何估计的临床改善值下,综合护理(IC)比强化专科转诊(ESR)更具成本效益的可能性较低。这表明临床环境在确定综合护理(IC)对心理健康的临床和成本效益方面的重要性。
局限性
我们的分析仅限于六个月的时间段且基于自我报告,未包括与生产力损失相关的社会成本和未来成本。
启示
这些结果表明全面整合有其优势,当存在这种整合时,进一步将行为健康护理整合到初级保健中可被视为改善老年人抑郁症的一种方式。强化专科转诊(ESR)在某些环境中可能具有成本效益这一发现也与政策相关。需要进一步研究分析非退伍军人事务部环境中强化专科转诊(ESR)成本的构成以及退伍军人事务部环境中综合护理(IC)的有效性。