Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Korean J Intern Med. 2010 Mar;25(1):71-6. doi: 10.3904/kjim.2010.25.1.71. Epub 2010 Feb 26.
BACKGROUND/AIMS: To characterize ultrasonographic findings in papillary thyroid carcinoma (PTC) combined with Graves' disease.
Medical records and ultrasonographic findings of 1,013 patients with Graves' disease and 3,380 patients without Graves' disease were analyzed retrospectively. A diagnosis of PTC was based on a pathologic examination.
The frequency of hypoechogenicity was lower in patients with PTC and Graves' disease than in patients with PTC alone (p < 0.05). The frequency of perinodular blood flow in patients with PTC and Graves' disease was significantly higher than in those with PTC alone (p < 0.05). PTC combined with Graves' disease was characterized by more ill-defined borders and less frequency of overall calcification, punctate calcification, and heterogeneous echogenicity, although the difference was not statistically significant.
Our results suggest that patients with Graves' disease more frequently have atypical PTC findings on ultrasonography.
背景/目的：描述合并 Graves 病的甲状腺乳头状癌（PTC）的超声表现。
回顾性分析了 1013 例 Graves 病患者和 3380 例无 Graves 病患者的病历和超声检查结果。PTC 的诊断基于病理检查。
与单纯 PTC 患者相比，合并 Graves 病的 PTC 患者的低回声频率更低（p<0.05）。合并 Graves 病的 PTC 患者的结节周围血流频率明显高于单纯 PTC 患者（p<0.05）。尽管差异无统计学意义，但合并 Graves 病的 PTC 表现为边界更不清楚，整体钙化、点状钙化和不均匀回声的频率更低。
我们的研究结果表明，Graves 病患者的超声检查更常出现不典型的 PTC 表现。
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