Institute of Dental Research, Nanjing Medical University, 140 Hanzhong Road, 210029 Nanjing, People's Republic of China.
Med Oncol. 2011 Mar;28(1):182-7. doi: 10.1007/s12032-010-9455-x. Epub 2010 Mar 2.
The common functional CYP2E1 Rsa I/Pst I polymorphism may influence the risk of esophageal cancer. However, the published results are conflicting. We therefore conducted a meta-analysis comprised of 11 published case-control studies with 1,088 cases and 2,238 controls. Odds ratios (ORs) with 95% confidence interval (CIs) were used to assess the strength of the association. Overall, the pooled ORs were 0.53 (95% CI = 0.31-0.89, P (heterogeneity) < 0.001) and 0.57 (95% CI = 0.34-0.96, P (heterogeneity) < 0.001), for the heterogeneity c1/c2 and c2 allele carriers (c1/c2 + c2/c2) compared with the homozygous c1/c2, respectively. In subgroup analysis by race, the same significant risks were found among Asians (for c2 vs. c1: OR = 0.64, 95% CI = 0.43-0.95, P (heterogeneity) < 0.001; for c1/c2 vs. c1/c1: OR = 0.48, 95% CI = 0.28-0.82, P (heterogeneity) < 0.001; for c1/c2 + c2/c2 vs. c1/c1: OR = 0.51, 95% CI = 0.30-0.86, P (heterogeneity) < 0.001). In conclusion, our meta-analysis demonstrates that CYP2E1 Rsa I/Pst I c2 allele may be a decreased risk factor for developing esophageal cancer among Asians populations.
常见的功能性 CYP2E1 Rsa I/Pst I 多态性可能会影响食管癌的风险。然而，已发表的结果存在冲突。因此，我们进行了一项荟萃分析，其中包括 11 项已发表的病例对照研究，共纳入 1088 例病例和 2238 例对照。使用比值比（OR）及其 95%置信区间（CI）来评估关联的强度。总体而言，与纯合子 c1/c1 相比，杂合子 c1/c2 和 c2 等位基因携带者（c1/c2+c2/c2）的合并 OR 分别为 0.53（95%CI=0.31-0.89，P（异质性）<0.001）和 0.57（95%CI=0.34-0.96，P（异质性）<0.001）。按种族进行亚组分析时，在亚洲人群中也发现了相同的显著风险（对于 c2 与 c1：OR=0.64，95%CI=0.43-0.95，P（异质性）<0.001；对于 c1/c2 与 c1/c1：OR=0.48，95%CI=0.28-0.82，P（异质性）<0.001；对于 c1/c2+c2/c2 与 c1/c1：OR=0.51，95%CI=0.30-0.86，P（异质性）<0.001）。综上所述，我们的荟萃分析表明，CYP2E1 Rsa I/Pst I c2 等位基因可能是亚洲人群罹患食管癌的一个降低风险因素。
