Division of Genetics and Physiology, Department of Biology, University of Turku, FIN-20014 Turku, Finland.
Mol Ecol. 2010 Apr;19(7):1273-82. doi: 10.1111/j.1365-294X.2010.04573.x. Epub 2010 Feb 24.
Using Atlantic salmon (Salmo salar) as a model system, we investigated whether 18 microsatellites tightly linked to immune-relevant genes have experienced different selection pressures than 76 loci with no obvious association with immune function. Immune-relevant loci were identified as outliers by two outlier tests significantly more often than nonimmune linked loci (22% vs. 1.6%). In addition, the allele frequencies of immune relevant markers were more often correlated with latitude and temperature. Combined, these results support the hypothesis that immune-relevant loci more frequently exhibit footprints of selection than other loci. They also indicate that the correlation between immune-relevant loci and latitude may be due to temperature-induced differences in pathogen-driven selection or some other environmental factor correlated with latitude.
利用大西洋三文鱼（Salmo salar）作为模型系统，我们研究了与免疫功能明显相关的 18 个紧密连锁的微卫星是否经历了不同于 76 个与免疫功能无明显关联的位点的不同选择压力。通过两种外显子测试，免疫相关基因座比非免疫相关基因座更频繁地被鉴定为异常值（22%比 1.6%）。此外，免疫相关标记的等位基因频率更频繁地与纬度和温度相关。综合这些结果支持这样的假设，即与免疫相关的基因座比其他基因座更频繁地表现出选择的痕迹。它们还表明，与免疫相关的基因座与纬度之间的相关性可能是由于温度引起的病原体驱动选择的差异或与纬度相关的其他环境因素。
