Morishita Takashi, Foote Kelly D, Haq Ihtsham U, Zeilman Pamela, Jacobson Charles E, Okun Michael S
Department of Neurology, University of Florida College of Medicine/Shands Hospital, Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA.
Stereotact Funct Neurosurg. 2010;88(2):98-104. doi: 10.1159/000289354. Epub 2010 Feb 27.
Dystonic tremor, which may present with many different clinical presentations (rhythmic oscillations, abnormal posture, pain, and/or a null point) has proven to be a challenge for the clinician to effectively treat. Although recent studies have demonstrated excellent outcomes in select cases following deep brain stimulation (DBS) of the internal globus pallidus, the optimal target for dystonia and particularly for dystonic tremor remains unknown. We report 3 cases of dystonic tremor which were successfully addressed through the use of ventral intermediate nucleus (Vim) DBS. We also review the literature concerning the efficacy of Vim DBS for addressing dystonia. This case series illustrates the potential use of Vim DBS for select cases of dystonic tremor.
肌张力障碍性震颤可能有多种不同的临床表现(节律性振荡、异常姿势、疼痛和/或零点),事实证明,这对临床医生进行有效治疗是一项挑战。尽管最近的研究表明,在对苍白球内侧部进行深部脑刺激(DBS)后的特定病例中取得了良好的效果,但肌张力障碍尤其是肌张力障碍性震颤的最佳靶点仍然未知。我们报告了3例通过使用腹中间核(Vim)DBS成功治疗的肌张力障碍性震颤病例。我们还回顾了有关Vim DBS治疗肌张力障碍疗效的文献。该病例系列说明了Vim DBS在特定肌张力障碍性震颤病例中的潜在应用。