Fraioli A, Serio A, Mennuni G, Ceccarelli F, Petraccia L, Campanella J, Fontana M, Nocchi S, Tanzi G, Grassi M, Valesini G
UOC Medicina Interna E, Terapia Medica e Medicina Termale, Scuola di Specializzazione in Medicina Termale, Sapienza Università di Roma, Roma, Italia.
Clin Ter. 2009;160(6):e63-74.
Many previous researches showed clinical benefits, effects on inflammatory mediators and pain, immune system, hormones and on the diencephalic-pituitary-adrenal axis. Our study evalues the efficacy of mud-bath therapy with mineral water from the Sillene Spring at Italy's Chianciano Spa in patients with osteoarthritis of the knee.
In study we compared: physical examination of the knee joint, visual analogue scale (VAS) assessment of pain, and Lequesne Algo-functional Index. Tests were performed in 61 patients divided into 2 groups. The group A underwent three full cycles of mud-bath therapy over 1 year's time, the group B did not. An observational longitudinal study was also conducted on the patients of group A, before and after completion of the treatment protocol. Statistical analyses were based on use of Pearson's chi² test, Student's t tests for paired and unpaired data.
The percentage of patients with no symptoms or mild symptoms was higher in group A than in group B (differences were highly significant); the mean value of VAS and the overall Lequesne indexes mean score reported in group A was significantly lower than that reported in group B. The same we observed comparing the clinical conditions of group A patients before and after mud-bath therapy. No adverse effects were observed in any of the patients in group A.
The mud-bath therapy at Chianciano Spa significantly improves the clinical conditions of patients with knee osteoarthritis and significantly reduces the frequency and severity of symptoms and the disability they cause.
此前许多研究表明了其临床益处、对炎症介质和疼痛、免疫系统、激素以及对间脑-垂体-肾上腺轴的影响。我们的研究评估了意大利基安贾诺温泉疗养地的锡耶纳泉矿泉水泥浴疗法对膝骨关节炎患者的疗效。
在本研究中，我们比较了：膝关节体格检查、疼痛视觉模拟量表（VAS）评估以及勒凯斯内功能指数。对61例患者进行了测试，并将其分为两组。A组在1年时间内接受了三个完整周期的泥浴疗法，B组未接受。还对A组患者在治疗方案完成前后进行了一项观察性纵向研究。统计分析基于使用Pearson卡方检验、配对和非配对数据的学生t检验。
A组无症状或症状轻微的患者百分比高于B组（差异非常显著）；A组报告的VAS平均值和勒凯斯内指数总分平均值显著低于B组。在比较A组患者泥浴治疗前后的临床状况时，我们也观察到了同样的情况。A组患者均未观察到不良反应。
基安贾诺温泉疗养地的泥浴疗法显著改善了膝骨关节炎患者的临床状况，并显著降低了症状的频率和严重程度以及它们所导致的残疾程度。
