Departamento de Física, Universidade Federal Rural de Pernambuco Dois Irmãos, 52171-900, Recife-PE, Brazil.
Evolution. 2010 Jul;64(7):1973-83. doi: 10.1111/j.1558-5646.2010.00981.x. Epub 2010 Feb 26.
The rate at which a population adapts to its environment is a cornerstone of evolutionary theory, and recent experimental advances in microbial populations have renewed interest in predicting and testing this rate. Efforts to understand the adaptation rate theoretically are complicated by high mutation rates, to both beneficial and deleterious mutations, and by the fact that beneficial mutations compete with each other in asexual populations (clonal interference). Testable predictions must also include the effects of population bottlenecks, repeated reductions in population size imposed by the experimental protocol. In this contribution, we integrate previous work that addresses each of these issues, developing an overall prediction for the adaptation rate that includes: beneficial mutations with probabilistically distributed effects, deleterious mutations of arbitrary effect, population bottlenecks, and clonal interference.
种群适应环境的速度是进化理论的基石，最近微生物种群的实验进展重新激发了人们预测和检验这一速度的兴趣。理论上理解适应速度的努力受到高突变率的影响，无论是有益突变还是有害突变，并且由于有益突变在无性种群中相互竞争（克隆干扰）。可测试的预测还必须包括种群瓶颈的影响，这是实验方案强制的种群规模的重复减少。在本贡献中，我们整合了之前解决这些问题的工作，为包括以下内容的适应速度做出了总体预测：具有概率分布效应的有益突变、任意效应的有害突变、种群瓶颈和克隆干扰。
