Wnt/β-连环蛋白信号通路在口腔组织发育和疾病中的作用。
Wnt/beta-catenin signaling in oral tissue development and disease.
机构信息
Institute for Regenerative Medicine at Scott & White Hospital, Texas A&M Health Science Center, Temple, TX 76502, USA.
出版信息
J Dent Res. 2010 Apr;89(4):318-30. doi: 10.1177/0022034510363373. Epub 2010 Mar 3.
Abstract
The Wnt/beta-catenin signaling pathway is one of several key conserved intercellular signaling pathways in animals, and plays fundamental roles in the proliferation, regeneration, differentiation, and function of many cell and tissue types. This pathway is activated in a dynamic manner during the morphogenesis of oral organs, including teeth, taste papillae, and taste buds, and is essential for these processes to occur normally. Conversely, forced activation of Wnt/beta-catenin signaling promotes the formation of ectopic teeth and taste papillae. In this review, we discuss our current understanding of the roles of Wnt/beta-catenin signaling in oral tissue development and in related human diseases, and the potential of manipulating this pathway for therapeutic purposes.
摘要
Wnt/β-连环蛋白信号通路是动物中几个关键的保守细胞间信号通路之一，在许多细胞和组织类型的增殖、再生、分化和功能中发挥着基本作用。该通路在口腔器官（包括牙齿、味觉乳头和味蕾）的形态发生过程中以动态方式激活，对于这些过程的正常发生至关重要。相反，Wnt/β-连环蛋白信号的强制激活会促进异位牙齿和味觉乳头的形成。在这篇综述中，我们讨论了我们目前对 Wnt/β-连环蛋白信号在口腔组织发育和相关人类疾病中的作用的理解，以及操纵该通路用于治疗目的的潜力。
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Dev Dyn. 2010 Jan;239(1):364-72. doi: 10.1002/dvdy.22106.
2
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3
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4
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