[罗马尼亚西北部酒精性慢性胰腺炎的自然病史]
[Natural history of alcoholic chronic pancreatitis in north-western Romania].
作者信息
Barbu S T, Vlad C, Cazacu M
机构信息
Facultatea de Medicină, Clinica Chirurgicală IV, Universitatea de Medicină si Farmacie "I. Haţieganu" Cluj-Napoca.
出版信息
Rev Med Chir Soc Med Nat Iasi. 2008 Jul-Sep;112(3):662-8.
AIM
To describe the natural history of alcoholic chronic pancreatitis (ACP) patients form north-western Romania.
METHODS
We performed a retrospective analysis and a subsequent prospective follow-up (mean = 7.3 years) of 99 patients with ACP. Average duration of ACP was 15.6 years.
RESULTS
Patients were mostly men (93%), with a mean age of 42.9 years at the time of operation and 35.7 years at the disease onset. Indications for surgery were: intractable pain (12%), complications (83%) and suspicion of malignancy (5%). During the evolution, 35 patients needed two to four surgical procedures. Calcifications developed in 63.6% of patients, steatorrhea in 41.4% and secondary diabetes in 43.4%.
CONCLUSION
ACP in north-western Romania is characterized by early onset of the disease and a severe evolution with multiple complications needing repeated surgery. The "burnout" of the disease, with calcifications, secondary diabetes and marked exocrine insufficiency leads to lasting pain relief.
目的
描述罗马尼亚西北部酒精性慢性胰腺炎（ACP）患者的自然病程。
方法
我们对99例ACP患者进行了回顾性分析及后续前瞻性随访（平均7.3年）。ACP的平均病程为15.6年。
结果
患者大多为男性（93%），手术时平均年龄为42.9岁，发病时平均年龄为35.7岁。手术指征为：顽固性疼痛（12%）、并发症（83%）及怀疑恶性肿瘤（5%）。在病程中，35例患者需要进行两到四次手术。63.6%的患者出现钙化，41.4%的患者出现脂肪泻，43.4%的患者出现继发性糖尿病。
结论
罗马尼亚西北部的ACP具有疾病发病早、病情严重且伴有多种并发症需要反复手术的特点。疾病的“耗竭”，伴有钙化、继发性糖尿病和明显的外分泌功能不全，可使疼痛持久缓解。
Zotero 插件