Division of Immunology, Transplantation, and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milan, Italy.
Hum Gene Ther. 2010 May;21(5):533-41. doi: 10.1089/hum.2010.033.
Adoptive T cell therapy is aimed at overcoming constraints of the endogenous immune response. In patients with malignancies, this approach is based on the possibility of administering sufficient numbers of tumor-reactive lymphocytes under conditions in which they will promote a therapeutic response. Although this strategy is potentially applicable to a vast number of malignancies, its efficacy, to date, has been limited. This is likely related to several factors including an insufficient persistence and reactivation of infused cells, insufficient tumor infiltration, and the presence of an immunosuppressive environment. Here, we review the importance of pretransplantation host conditioning and posttransplantation strategies that have been shown to contribute to the therapeutic efficacy of infused T lymphocytes.
过继性 T 细胞疗法旨在克服内源性免疫反应的限制。在患有恶性肿瘤的患者中，这种方法基于在可以促进治疗反应的条件下给予足够数量的肿瘤反应性淋巴细胞的可能性。尽管这种策略可能适用于大量的恶性肿瘤，但迄今为止，其疗效有限。这可能与几个因素有关，包括输注细胞的持久性和再激活不足、肿瘤浸润不足以及存在免疫抑制环境。在这里，我们回顾了移植前宿主调理和移植后策略的重要性，这些策略已被证明有助于输注的 T 淋巴细胞的治疗效果。
