Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
J Inorg Biochem. 2010 May;104(5):583-91. doi: 10.1016/j.jinorgbio.2010.01.011. Epub 2010 Feb 11.
A new ligand 2-((2-((benzo[d]oxazol-2-yl)methoxy)phenoxy)methyl)benzoxazole (L) and its four transition metal complexes M(NO(3))(2)L (M=Cu, Co, Ni, Zn), have been synthesized and investigated. The single crystal structures of the complexes show that all of them have similar molecular structure and the ligand exhibits good coplanarity after coordination with the metal ions. Further investigation of DNA binding indicates that both the ligand L and the complexes can bond to DNA by intercalation mode, and the latter possesses much stronger binding affinity. Antitumor activity of these compounds tested on the four cancer cell lines, follows the order: Cu-L>Ni-L approximately Co-L>Zn-L>>L, which are thought to be related with their DNA-binding affinity.
一种新的配体 2-((2-((苯并[d]恶唑-2-基)甲氧基)苯氧基)甲基)苯并恶唑 (L) 及其四个过渡金属配合物 M(NO(3))(2)L（M=Cu、Co、Ni、Zn）已被合成并进行了研究。配合物的单晶结构表明，它们都具有相似的分子结构，并且配体在与金属离子配位后表现出良好的共面性。进一步的 DNA 结合研究表明，配体 L 和配合物都可以通过嵌入模式与 DNA 结合，而后者具有更强的结合亲和力。对四种癌细胞系进行的这些化合物的抗肿瘤活性测试表明，其顺序为：Cu-L>Ni-L≈Co-L>Zn-L>>L，这被认为与它们的 DNA 结合亲和力有关。
