Department of Pathology, Pusan National University School of Medicine, Yang-san, Korea.
J Clin Pathol. 2010 Mar;63(3):270-4. doi: 10.1136/jcp.2009.074104.
Gastroblastoma is a rare gastric epitheliomesenchymal biphasic tumour composed of spindle and epithelial cells, reported by Miettinen et al in a series of three cases in 2009. All those cases arose in stomachs of young adults. Neither the epithelial nor the mesenchymal component displayed sufficient atypia to diagnose a carcinosarcoma or other malignancy. On immunohistochemistry, the epithelial component expressed cytokeratin, and the mesenchymal component was positive for vimentin and CD10. Miettinen et al designated these neoplasms as gastroblastomas based on their similarities with other childhood blastomas such as pleuropulmonary blastoma and nephroblastoma. This report describes a probable fourth case of this unique type of neoplasm. The present case arose in the gastric antrum of a 9-year-old boy. While similarities were evident with the other cases, there were some differences. The epithelial component was more predominant and showed more mature morphology. Immunohistochemically, the epithelial component showed immunolabelling for c-KIT and CD56. The mesenchymal component was only focally positive for CD10. Ultrastructually, desmosomes and microvilli were found supporting a truly epithelial lesion.
胃母细胞瘤是一种罕见的胃上皮间质双相肿瘤，由 Miettinen 等人在 2009 年的一系列三例报告中提出。所有这些病例均发生于年轻成年人的胃中。上皮细胞和间质细胞均无足够的异型性来诊断癌肉瘤或其他恶性肿瘤。免疫组织化学染色显示，上皮细胞成分表达细胞角蛋白，间质细胞成分阳性表达波形蛋白和 CD10。Miettinen 等人根据这些肿瘤与儿童期其他胚细胞瘤（如肺胸膜胚细胞瘤和肾胚细胞瘤）的相似性，将这些肿瘤命名为胃母细胞瘤。本报告描述了这种独特类型肿瘤的可能第四例。本例发生于 9 岁男孩的胃窦部。虽然与其他病例有明显的相似之处，但也存在一些差异。上皮细胞成分更占优势，形态更成熟。免疫组织化学染色显示，上皮细胞成分对 c-KIT 和 CD56 有免疫标记。间质细胞仅局灶性表达 CD10。电镜下，发现桥粒和微绒毛，支持真正的上皮病变。
