吗啡给药对大鼠脑内儿茶酚胺水平的影响；下丘脑肾上腺素浓度的特异性降低。

Effects of morphine administration on catecholamine levels in rat brain; specific reduction of epinephrine concentration in hypothalamus.

作者信息

Ota M, Mefford I N, Naoi M, Linnoila M

机构信息

Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, MD 20892.

出版信息

Neurosci Lett. 1991 Jan 2;121(1-2):129-32. doi: 10.1016/0304-3940(91)90666-h.

DOI:10.1016/0304-3940(91)90666-h

PMID:2020369

Abstract

The effects of morphine administration on concentrations of epinephrine, norepinephrine and dopamine were examined in the rat brain. Morphine injection reduced the epinephrine level only in the hypothalamus, while the norepinephrine level was reduced in the hypothalamus, medulla, and locus coeruleus. The dopamine concentration was elevated in all regions examined. These changes were blocked by administration of naloxone. Repeated injection of morphine for 14 days did not affect any catecholamine level. In naloxone-induced withdrawal, epinephrine was most markedly depleted in hypothalamus. These observations suggest that the epinephrine level in hypothalamus is affected by morphine acting on opioid receptors.

摘要

研究了吗啡给药对大鼠脑内肾上腺素、去甲肾上腺素和多巴胺浓度的影响。注射吗啡仅使下丘脑的肾上腺素水平降低，而下丘脑、延髓和蓝斑核中的去甲肾上腺素水平降低。在所检查的所有区域中多巴胺浓度均升高。这些变化可被纳洛酮给药阻断。连续14天重复注射吗啡不影响任何儿茶酚胺水平。在纳洛酮诱导的戒断过程中，下丘脑的肾上腺素耗竭最为明显。这些观察结果表明，下丘脑的肾上腺素水平受作用于阿片受体的吗啡影响。