过氧化物酶体增殖物激活受体γ与肺动脉高压的病理生物学。

PPARgamma and the pathobiology of pulmonary arterial hypertension.

机构信息

The Wall Center for Pulmonary Vascular Diseases, Stanford University School of Medicine, Stanford, CA, USA.

出版信息

Adv Exp Med Biol. 2010;661:447-58. doi: 10.1007/978-1-60761-500-2_29.

PMID:20204748

Abstract

Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor that functions as a transcription factor to regulate adipogenesis and metabolism by binding to PPAR response elements (PPAREs) in the promoter region of various target genes. Activation of PPARgamma suppresses smooth muscle cell proliferation and migration. This chapter discusses the potential protective role of PPARgamma and its downstream signaling cascades in the development of pulmonary arterial hypertension. Furthermore, the chapter also provides an overview on the cellular and molecular mechanisms involved in PPARgamma-mediated inhibitory effect on pulmonary vascular remodeling, a major contributor to the elevated pulmonary vascular resistance in patients with pulmonary arterial hypertension.

摘要

过氧化物酶体增殖物激活受体 γ（PPARγ）是一种核受体，作为转录因子通过与各种靶基因启动子区域中的 PPAR 反应元件（PPARE）结合来调节脂肪生成和代谢。PPARγ 的激活抑制平滑肌细胞增殖和迁移。本章讨论了 PPARγ 及其下游信号级联在肺动脉高压发展中的潜在保护作用。此外，本章还概述了 PPARγ 介导的对肺血管重塑的抑制作用涉及的细胞和分子机制，这是肺动脉高压患者肺血管阻力升高的主要原因。