在可独立行走的脑瘫儿童和青少年中持续鞘内注射巴氯芬后步态的变化
Changes in gait following continuous intrathecal baclofen infusion in ambulant children and young adults with cerebral palsy.
作者信息
Brochard Sylvain, Lempereur Mathieu, Filipetti Paul, Rémy-Néris Olivier
机构信息
CHU Brest, Service Médecine Physique et de Réadaptation, Brest, France.
出版信息
Dev Neurorehabil. 2009;12(6):397-405. doi: 10.3109/17518420903062767.
OBJECTIVE
To assess the effect of continuous intrathecal baclofen infusion (ITB) on gait parameters of ambulant children with cerebral palsy (CP).
METHODS
The assessment before and 16 months after ITB on seven children with CP (mean age 15 years, SD 5.4) included: Ashworth scale score, range of motion (hip, knee, ankle), Gillette functional assessment questionnaire (FAQ), joint kinematics, spatiotemporal parameters and Gillette Gait Index (GGI).
RESULTS
Gillette FAQ significantly improved from 6.1 to 7.1. Mean GGI improved from 554.50 to 489.25, which was not significant although the improvement was large for three children. Parameters in the sagittal plane were significantly modified with a significant increase in step length (0.65 m to 0.74 m) and a significant increase in hip extension during stance phase (32.25 degrees to 21.6 degrees ). These results were correlated to clinical assessments.
CONCLUSION
ITB seems to improve sagittal gait parameters of children and young adults with CP.
目的
评估鞘内持续注射巴氯芬（ITB）对能行走的脑瘫（CP）儿童步态参数的影响。
方法
对7名CP儿童（平均年龄15岁，标准差5.4）在ITB治疗前及治疗16个月后进行的评估包括：Ashworth量表评分、活动范围（髋、膝、踝）、吉列功能评估问卷（FAQ）、关节运动学、时空参数和吉列步态指数（GGI）。
结果
吉列FAQ从6.1显著提高到7.1。平均GGI从554.50提高到489.25，虽然有3名儿童的改善幅度较大，但差异无统计学意义。矢状面参数有显著改变，步长显著增加（从0.65米增加到0.74米），站立期髋伸展显著增加（从32.25度增加到21.6度）。这些结果与临床评估相关。
结论
ITB似乎能改善CP儿童和青年的矢状面步态参数。
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