School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
J Int Soc Sports Nutr. 2010 Jan 29;7(1):6. doi: 10.1186/1550-2783-7-6.
The effects of creatine (CR) supplementation on glycogen content are still debatable. Thus, due to the current lack of clarity, we investigated the effects of CR supplementation on muscle glycogen content after high intensity intermittent exercise in rats.
First, the animals were submitted to a high intensity intermittent maximal swimming exercise protocol to ensure that CR-supplementation was able to delay fatigue (experiment 1). Then, the CR-mediated glycogen sparing effect was examined using a high intensity intermittent sub-maximal exercise test (fixed number of bouts; six bouts of 30-second duration interspersed by two-minute rest interval) (experiment 2). For both experiments, male Wistar rats were given either CR supplementation or placebo (Pl) for 5 days.
As expected, CR-supplemented animals were able to exercise for a significant higher number of bouts than Pl. Experiment 2 revealed a higher gastrocnemius glycogen content for the CR vs. the Pl group (33.59%). Additionally, CR animals presented lower blood lactate concentrations throughout the intermittent exercise bouts compared to Pl. No difference was found between groups in soleus glycogen content.
The major finding of this study is that CR supplementation was able to spare muscle glycogen during a high intensity intermittent exercise in rats.
肌酸（CR）补充对糖原含量的影响仍存在争议。因此，由于目前缺乏明确性，我们研究了 CR 补充对大鼠高强度间歇运动后肌肉糖原含量的影响。
首先，动物进行高强度间歇最大游泳运动方案，以确保 CR 补充能够延迟疲劳（实验 1）。然后，使用高强度间歇亚最大运动测试（固定的回合数；六个 30 秒持续时间的回合，穿插两分钟的休息间隔）检查 CR 介导的糖原节省效应（实验 2）。对于这两个实验，雄性 Wistar 大鼠接受 CR 补充或安慰剂（Pl）连续 5 天。
正如预期的那样，CR 补充的动物能够进行显著更多的回合。实验 2显示 CR 组比 Pl 组的比目鱼肌糖原含量更高（33.59%）。此外，与 Pl 相比，CR 动物在间歇运动回合中血液乳酸浓度较低。两组之间的比目鱼肌糖原含量没有差异。
本研究的主要发现是，CR 补充能够在大鼠的高强度间歇运动中节省肌肉糖原。
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