Neonatal Care Unit, Regina Margherita Children's Hospital, Department of Pediatrics, University of Turin, Italy.
Ital J Pediatr. 2010 Jan 18;36:6. doi: 10.1186/1824-7288-36-6.
The perfusion index, derived from the pulse oximeter signal, seems to be an accurate predictor for high illness severity in newborns. The aim of this study was to determine the perfusion index values of clinically and hemodynamically stable preterm newborns in the first week of life.
Perfusion index recordings were performed on the first, third and seventh day of life on 30 preterm newborns. Their state of health was assessed according to clinical and behaviour evaluation and to the Score for Neonatal Acute Physiology.
The median(interquartile range) perfusion index values were 0.9(0.6) on the first, 1.2(1.0) on the third, and 1.3(0.9) on the seventh day, with a significant increase between the first and the third day.
Perfusion index proved to be an easily applicable, non-invasive method for monitoring early postnatal changes in peripheral perfusion. Its trend during the first week of life suggests that its clinical application should take age into account. Further studies are needed to obtain reference perfusion index values from a larger sample of preterm newborns, to identify specific gestational age-related cut-off values for illness and to test the role of perfusion index in monitoring critically ill neonates.
来自脉搏血氧仪信号的灌注指数似乎是预测新生儿高疾病严重程度的准确指标。本研究旨在确定生命第一周临床和血流动力学稳定的早产儿的灌注指数值。
对 30 名早产儿在出生后的第 1、3、7 天进行灌注指数记录。根据临床和行为评估以及新生儿急性生理学评分来评估他们的健康状况。
灌注指数中位数（四分位距）分别为第 1 天 0.9（0.6）、第 3 天 1.2（1.0）、第 7 天 1.3（0.9），第 1 天和第 3 天之间有显著增加。
灌注指数被证明是一种易于应用的、非侵入性的监测外周灌注早期变化的方法。其在生命第一周的趋势表明，其临床应用应考虑年龄因素。需要进一步的研究来从更大的早产儿样本中获得参考灌注指数值，确定与疾病相关的特定胎龄截断值，并测试灌注指数在监测危重新生儿中的作用。
