Tribut Olivier, Bentué-Ferrer Danièle, Verdier Marie-Clémence
Laboratoire de Pharmacologie Biologique, CHU Pontchaillou, Rennes, France.
Therapie. 2010 Jan-Feb;65(1):57-60. doi: 10.2515/therapie/2009069. Epub 2010 Mar 8.
Gabapentin is a structural analogue of GABA used in the treatment of the partial epilepsies of adult and child of more than 12 years, in monotherapy or in association with other anticonvulsant drugs. In association, gabapentin presents the advantage of not interfering with the other anticonvulsant drugs. The interindividual pharmacokinetic variability and the saturable absorption are, with the adaptation in case of renal insufficiency, the only arguments in favor of TDM. During clinical studies, the plasma concentrations of gabapentin were generally included between 2 and 20 mg/L. For this molecule, the level of proof of the interest of therapeutic drug monitoring was estimated in: possibly useful.
加巴喷丁是γ-氨基丁酸（GABA）的结构类似物，用于治疗12岁及以上成人和儿童的部分性癫痫，可单药治疗或与其他抗惊厥药物联合使用。联合使用时，加巴喷丁具有不干扰其他抗惊厥药物的优点。个体间药代动力学变异性和饱和性吸收，以及肾功能不全时的剂量调整，是支持进行治疗药物监测（TDM）的唯一理由。在临床研究中，加巴喷丁的血浆浓度一般在2至20mg/L之间。对于该药物，治疗药物监测的获益证据水平评估为：可能有用。
