Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304, United States.
Cell Signal. 2010 Aug;22(8):1175-84. doi: 10.1016/j.cellsig.2010.03.001. Epub 2010 Mar 4.
The Src, Syk, and Tec family kinases are three of the most well characterized tyrosine kinase families found in the human genome. Members of these kinase families function downstream of antigen and F(c) receptors in hematopoietic cells and transduce signals leading to calcium mobilization, altered gene expression, cytokine production, and cell proliferation. Over the last several years, structural and biochemical studies have begun to uncover the molecular mechanisms regulating activation of these kinases. It appears that each kinase family functions as a distinct type of molecular switch. This review discusses the activation of the Src, Syk, and Tec kinases from the perspective of structure, phosphorylation, allosteric regulation, and kinetics. The multiple factors that regulate the Src, Syk, and Tec families illustrate the important role played by each of these kinases in immune cell signaling.
Src、Syk 和 Tec 家族激酶是人类基因组中最具特征的三种酪氨酸激酶家族。这些激酶家族的成员在造血细胞中抗原和 F(c)受体的下游发挥作用，并传递信号导致钙动员、基因表达改变、细胞因子产生和细胞增殖。在过去的几年中，结构和生化研究开始揭示调节这些激酶激活的分子机制。似乎每种激酶家族都作为一种独特类型的分子开关发挥作用。这篇综述从结构、磷酸化、变构调节和动力学的角度讨论了 Src、Syk 和 Tec 激酶的激活。调节 Src、Syk 和 Tec 家族的多种因素说明了这些激酶在免疫细胞信号转导中所起的重要作用。
