Institute of Animal Nutrition and Nutrition Physiology, Justus-Liebig-Universität Giessen, Giessen, Germany.
Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):189-98. doi: 10.1016/j.plefa.2010.02.022. Epub 2010 Mar 7.
The endothelium is critical for the maintenance of a proper vessel function. Disturbances of endothelial function, called endothelial dysfunction, have serious implications, and lead to the development of atherosclerosis. It is well established that the risk for atherosclerosis development is influenced by nutritional factors such as the intake of certain fatty acids. Due to the fundamental role of the endothelium for atherosclerosis development, it is, therefore, likely that fatty acids directly influence the function of endothelial cells. The present review aims to explain the divergent effects of different types of fatty acids on cardiovascular disease risk by summarizing in vitro-data on the effects of fatty acids on (1) important signalling pathways involved in the modulation of endothelial cell function, and (2) endothelial cell functional properties, namely vasoactive mediator release and mononuclear cell recruitment, both of which are typically dysregulated during endothelial dysfunction.
内皮细胞对于维持血管正常功能至关重要。内皮功能障碍（即内皮功能紊乱）会导致严重后果，并引发动脉粥样硬化。众所周知，动脉粥样硬化的发展风险受到营养因素的影响，例如某些脂肪酸的摄入。由于内皮细胞对于动脉粥样硬化的发展起着重要作用，因此，脂肪酸可能会直接影响内皮细胞的功能。本综述旨在通过总结体外研究数据，解释不同类型的脂肪酸对心血管疾病风险的不同影响，这些数据涉及（1）参与调节内皮细胞功能的重要信号通路，以及（2）内皮细胞的功能特性，即血管活性介质的释放和单核细胞的募集，这些在内皮功能障碍期间通常会失调。
