Kovalev V A, Karaguzhin S G, Koroleva S V, Abdulkhamidov A N, Levadnaia M G
Urologiia. 2009 Sep-Oct(5):45-8.
Clinical experience of the authors on patients with Peyronie's disease shows that intraplaque therapy with verapamil and interferon and a malignant course of the disease can result in shortening of the penis (4 and 1 cases were observed, respectively). The length of the penis diminished by 30 to 50%. The patients were treated with graft corporoplasty with endoprosthesis of the penis. Basing on the experience with these cases the following conclusions were made: intraplaque injections are hard to perform and can provoke progression of the disease; long-term conservative treatment for stabilization of the active stage of Peyronie's disease can lead to shortening of the penis; in malignant course of the disease and progressive shortening of the penis surgical policy is justified despite "acute" phase of the disease.
作者对佩罗尼氏病患者的临床经验表明,用维拉帕米和干扰素进行斑块内治疗以及疾病的恶性病程可导致阴茎缩短(分别观察到4例和1例)。阴茎长度减少了30%至50%。对这些患者进行了阴茎假体植入的移植性阴茎成形术治疗。基于这些病例的经验得出以下结论:斑块内注射难以实施,且可引发疾病进展;对佩罗尼氏病活跃期进行长期保守治疗可导致阴茎缩短;在疾病的恶性病程和阴茎逐渐缩短的情况下,尽管处于疾病的“急性期”,手术治疗策略仍是合理的。