Dipartimento di Ingegneria Biomedica, Elettronica e delle Telecomunicazioni Università di Napoli Federico II, 80125 Napoli, Italia.
Int J Hyperthermia. 2010;26(4):389-403. doi: 10.3109/02656730903514685.
Two points are particularly relevant for the clinical use of magnetic nanoparticle hyperthermia: the optimisation of both the exposure conditions and the magnetic nanoparticle characteristics, and the assessment of the limits of scalability of the treatment. To answer these two points a criterion for the individuation of the magnetic field parameters and of the magnetic nanoparticle features that minimise the therapeutic concentration of nanoparticles to be used in magnetic nanoparticle hyperthermia is developed.
The proposed criterion is based on the estimation of the levels of heat generation rate, due to the electromagnetic field, to be supplied to both the cancerous and the neighbouring healthy tissues for achieving the therapeutic heating of the tumour with a desired degree of spatial selectivity. These quantities are determined by exploiting the Pennes bioheat transfer model.
The reliability of the criterion has been proven by means of an extensive numerical analysis, performed by considering tumours of spherical shape embedded in tissues of cylindrical shape. Several cases, including tumours of different sizes and position have been considered.
By exploiting the proposed criterion a study of the clinical scalability of the therapeutic approach is presented.
对于磁纳米粒子热疗的临床应用，有两点特别重要：优化暴露条件和磁纳米粒子特性，以及评估治疗的可扩展性极限。为了回答这两个问题，开发了一种用于确定最小化磁纳米粒子热疗中使用的纳米粒子治疗浓度的磁场参数和磁纳米粒子特征的标准。
所提出的标准基于对热生成率水平的估计，这些水平是由于电磁场而提供给癌变组织和相邻健康组织的，以实现对肿瘤的治疗性加热，具有所需的空间选择性程度。这些量是通过利用 Pennes 生物传热模型来确定的。
通过考虑嵌入圆柱形组织中的球形肿瘤进行广泛的数值分析，证明了该标准的可靠性。考虑了多种情况，包括不同大小和位置的肿瘤。
通过利用所提出的标准，提出了对治疗方法临床可扩展性的研究。
