猫免疫缺陷病毒（FIV）作为慢病毒感染研究的模型：与HIV的相似之处
Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV.
作者信息
Elder John H, Lin Ying-Chuan, Fink Elizabeth, Grant Chris K
机构信息
Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA.
出版信息
Curr HIV Res. 2010 Jan;8(1):73-80. doi: 10.2174/157016210790416389.
Abstract
FIV is a significant pathogen in the cat and is, in addition, the smallest available natural model for the study of lentivirus infections. Although divergent at the amino acid level, the cat lentivirus has an abundance of structural and pathophysiological commonalities with HIV and thus serves well as a model for development of intervention strategies relevant to infection in both cats and man. The following review highlights both the strengths and shortcomings of the FIV/cat model, particular as regards development of antiviral drugs.
摘要
猫免疫缺陷病毒（FIV）是猫的一种重要病原体，此外，它还是研究慢病毒感染可用的最小天然模型。尽管在氨基酸水平上存在差异，但猫慢病毒与人类免疫缺陷病毒（HIV）在结构和病理生理学方面有许多共同之处，因此可很好地作为开发与猫和人类感染相关干预策略的模型。以下综述重点介绍了FIV/猫模型的优点和缺点，特别是在抗病毒药物开发方面。
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