多发性运动神经病患者 HLA-DRB1*15 频率增加。
Increased frequency of HLA-DRB1*15 in patients with multifocal motor neuropathy.
机构信息
Department of Neurology, G03.228, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, the Netherlands.
出版信息
Neurology. 2010 Mar 9;74(10):828-32. doi: 10.1212/WNL.0b013e3181d3e2f6.
OBJECTIVES
The favorable response to treatment with IV immunoglobulins and the presence of IgM antibodies to the glycolipid GM1 are indications that inflammation underlies multifocal motor neuropathy (MMN) pathogenesis. We investigated the association of MMN with human leukocyte antigen (HLA) class I and II antigens.
METHODS
HLA class I and II antigens of 74 Dutch patients with MMN and 700 controls were determined in a case-control study. Associations of HLA types with MMN disease characteristics were investigated.
RESULTS
Compared with controls, patients with MMN had higher frequencies of HLA-DRB1*15 (41 vs 24%, p = 0.0017). Disease characteristics were not associated with specific HLA types.
CONCLUSIONS
Similar associations were found in patients with multiple sclerosis and women with chronic immune-mediated demyelinating neuropathy, which may suggest that these demyelinating disorders share pathogenic mechanisms.
目的
静脉注射免疫球蛋白治疗有效，以及存在针对神经节苷脂 GM1 的 IgM 抗体，这些都表明炎症是多发性运动神经病（MMN）发病机制的基础。我们研究了 MMN 与人类白细胞抗原（HLA）I 类和 II 类抗原之间的关系。
方法
在一项病例对照研究中，我们确定了 74 例荷兰 MMN 患者和 700 名对照者的 HLA I 类和 II 类抗原。研究了 HLA 类型与 MMN 疾病特征的关联。
结果
与对照组相比，MMN 患者 HLA-DRB1*15 频率更高（41%比 24%，p=0.0017）。疾病特征与特定的 HLA 类型无关。
结论
在多发性硬化症患者和慢性免疫介导的脱髓鞘神经病女性中也发现了类似的关联，这可能表明这些脱髓鞘疾病具有共同的发病机制。
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