长期干扰素-α治疗抑制肝癌肿瘤生长但促进转移能力。
Long-term interferon-α treatment suppresses tumor growth but promotes metastasis capacity in hepatocellular carcinoma.
机构信息
Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
出版信息
J Cancer Res Clin Oncol. 2010 Dec;136(12):1891-900. doi: 10.1007/s00432-010-0848-1. Epub 2010 Mar 6.
PURPOSE
To elucidate the effect of IFN-α treatment on tumor growth and metastasis of hepatocellular carcinoma (HCC).
METHODS
IFN-α administration was conducted in nude mice using an orthotopic implantation model of human HCC, and the key molecular markers in the IFN-α treatment was detected by immunohistochemistry staining and PCR array.
RESULTS
Up to 12 weeks of IFN-α treatment significantly suppressed tumor growth of HCC, but relatively increased the number of circulating tumor cells, which might be due to the enhanced tumor hypoxia as well as up-regulation of metastasis-related genes, such as HIF-1α, c-met, u-PA, PDGF-A, and IL-8. However, IFN-α had no direct effect on migration and invasion of HCC cells.
CONCLUSIONS
IFN-α has janus face of consistently suppressing HCC growth, however, promoting tumor metastasis capacity, which is of clinical indication for the scientific administration of IFN-α and the similar antiangiogenesis drugs for their dual effect on tumor growth and metastasis.
目的
阐明 IFN-α 治疗对肝细胞癌（HCC）肿瘤生长和转移的影响。
方法
通过人 HCC 原位种植模型，在裸鼠中进行 IFN-α 给药，并通过免疫组织化学染色和 PCR 阵列检测 IFN-α 治疗中的关键分子标志物。
结果
长达 12 周的 IFN-α 治疗显著抑制 HCC 肿瘤生长，但相对增加了循环肿瘤细胞的数量，这可能是由于肿瘤缺氧增强以及转移相关基因（如 HIF-1α、c-met、u-PA、PDGF-A 和 IL-8）的上调所致。然而，IFN-α 对 HCC 细胞的迁移和侵袭没有直接影响。
结论
IFN-α 具有两面性，一方面持续抑制 HCC 生长，另一方面促进肿瘤转移能力，这为 IFN-α 和类似的抗血管生成药物的临床应用提供了依据，因为它们对肿瘤生长和转移具有双重作用。
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