胆固醇跨小肠刷状缘膜转运的蛋白质介质。
Protein mediators of sterol transport across intestinal brush border membrane.
作者信息
Brown J Mark, Yu Liqing
机构信息
Department of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
出版信息
Subcell Biochem. 2010;51:337-80. doi: 10.1007/978-90-481-8622-8_12.
Abstract
Dysregulation of cholesterol balance contributes significantly to atherosclerotic cardiovascular disease (ASCVD), the leading cause of death in the United States. The intestine has the unique capability to act as a gatekeeper for entry of cholesterol into the body, and inhibition of intestinal cholesterol absorption is now widely regarded as an attractive non-statin therapeutic strategy for ASCVD prevention. In this chapter we discuss the current state of knowledge regarding sterol transport across the intestinal brush border membrane. The purpose of this work is to summarize substantial progress made in the last decade in regards to protein-mediated sterol trafficking, and to discuss this in the context of human disease.
摘要
胆固醇平衡失调是美国头号死因——动脉粥样硬化性心血管疾病（ASCVD）的重要成因。肠道具有独特能力，可作为胆固醇进入人体的把关者，目前，抑制肠道胆固醇吸收被广泛视为一种有吸引力的非他汀类ASCVD预防治疗策略。在本章中，我们将讨论关于固醇跨肠刷状缘膜转运的现有知识状况。这项工作的目的是总结过去十年在蛋白质介导的固醇运输方面取得的重大进展，并在人类疾病背景下进行讨论。
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