Department of Medicine, Internal Intensive Care and Nephrology, Charité - Universitätsmedizin Berlin/Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.
Expert Rev Mol Diagn. 2010 Mar;10(2):159-71. doi: 10.1586/erm.10.2.
Whole-blood choline, plasma choline and serum choline are emerging biomarkers in acute coronary syndrome related to coronary plaque instability with platelet thrombus formation and ischemia. Whole-blood choline is an early predictor for cardiac events, which adds to troponins, natriuretic peptides and inflammatory markers. Serum choline is highly predictive for myocardial infarction and discriminates high- from low-risk subgroups in troponin-positive patients. Choline is a candidate marker to aid decision making in the emergency room in the upcoming era of sensitive troponin tests and the growing need to differentiate between ischemic and nonischemic etiologies of troponin elevations. The integrated approach of in vitro choline measurement in combination with advanced techniques of in vivo choline imaging represents a novel future strategy for detecting vulnerable plaques. This paper provides an up-to-date review of choline in acute coronary syndrome including key aspects of pathophysiology, analytical methods, clinical studies and implications for the integrated assessment of plaque vulnerability.
全血胆碱、血浆胆碱和血清胆碱是急性冠状动脉综合征相关的新兴生物标志物，与冠状动脉斑块不稳定、血小板血栓形成和缺血有关。全血胆碱是心脏事件的早期预测指标，可与肌钙蛋白、利钠肽和炎症标志物一起使用。血清胆碱对心肌梗死具有高度预测性，并可区分肌钙蛋白阳性患者中的高危和低危亚组。胆碱是候选标志物，可在即将到来的敏感肌钙蛋白检测时代以及区分肌钙蛋白升高的缺血性和非缺血性病因的需求日益增长的情况下，帮助急诊科做出决策。体外胆碱测量与体内胆碱成像的先进技术相结合的综合方法代表了一种新的未来策略，用于检测易损斑块。本文对急性冠状动脉综合征中的胆碱进行了最新综述，包括病理生理学、分析方法、临床研究和对斑块易损性综合评估的影响等关键方面。
