伊朗伊斯法罕地区肌萎缩侧索硬化症的流行病学。

Epidemiology of amyotrophic lateral sclerosis in Isfahan, Iran.

机构信息

Medical Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Eur J Neurol. 2010 Jul;17(7):984-9. doi: 10.1111/j.1468-1331.2010.02972.x. Epub 2010 Feb 28.

DOI:10.1111/j.1468-1331.2010.02972.x

PMID:20214678

Abstract

BACKGROUND

Few studies are carried out on the epidemiology of amyotrophic lateral sclerosis (ALS) in Middle East with no reports from Iran.

OBJECTIVE

To determine the epidemiological and clinical features of ALS amongst the Iranian population living in Isfahan, Iran.

METHODS

Medical records of all hospitals with a neurology department and outpatient neurology clinics in Isfahan province from 2002 to 2006 were reviewed, and all patients with the diagnosis of ALS according to El Escorial diagnostic criteria were extracted and related demographic and clinical data were gathered and analyzed.

RESULTS

We found 98 new patients (66 men and 32 women) with definite, probable, or possible ALS. The average annual incidence was 0.42/100,000, with the highest incidence rate amongst those aged 70-74. On 21 March 2006, the crude prevalence was 1.57/100,000. Median survival from onset was 48 months (95% confidence interval 34-61) and survival rates for 1, 3,and 5 years after the onset were 94%, 66%, and 32%, respectively.

CONCLUSIONS

The incidence and prevalence of ALS in the Iranian population seems to be lower compared to other populations and the survival of patients was longer than previously reported.

摘要

背景

在中东地区，针对肌萎缩性侧索硬化症（ALS）的流行病学研究较少，伊朗也尚无相关报告。

目的

旨在确定居住在伊朗伊斯法罕的伊朗人群中 ALS 的流行病学和临床特征。

方法

对 2002 年至 2006 年期间伊斯法罕省所有拥有神经内科的医院和神经内科门诊的病历进行了回顾，根据埃尔埃斯科里亚尔诊断标准提取出所有被诊断为 ALS 的患者，并收集了相关的人口统计学和临床数据进行分析。

结果

我们共发现了 98 例新确诊的、可能的或很可能的 ALS 患者（66 名男性和 32 名女性）。平均年发病率为 0.42/100,000，发病率最高的是 70-74 岁年龄段的人群。2006 年 3 月 21 日，粗患病率为 1.57/100,000。发病后中位生存时间为 48 个月（95%置信区间 34-61），发病后 1、3 和 5 年的生存率分别为 94%、66%和 32%。