Hemingway D M, Cooke T G, Chang D, Grime S J, Jenkins S A
University Department of Surgery, Royal Infirmary, Glasgow, UK.
Br J Cancer. 1991 Apr;63(4):495-8. doi: 10.1038/bjc.1991.118.
Regional chemotherapy for colorectal liver metastases has not demonstrated a convincing survival benefit over systemic chemotherapy. This may be due to poor delivery of chemotherapeutic drugs to hypovascular liver tumour. Since vasoactive agents may influence hepatic blood flow this study investigated the effects of systemic and regional vasoconstrictors on the delivery of a regionally delivered marker in an experimental model of liver tumour. Systemic administration of angiotensin II caused a significant retention of marker in normal liver, but not in tumour compared to controls. Regional delivery of angiotensin II and phenylephrine caused significantly greater retention of marker in tumour than liver with an overall 4-fold increased retention of marker one minute after its injection. Ninety minutes after injection there was still significant retention of marker compared to control animals. Regional delivery of hepatic artery vasoconstrictors increase delivery of marker and may increase delivery of chemotherapeutic drug to liver tumour.
结直肠癌肝转移的区域化疗相对于全身化疗尚未显示出令人信服的生存获益。这可能是由于化疗药物向乏血管性肝肿瘤的递送不佳所致。由于血管活性药物可能会影响肝血流,本研究在肝肿瘤实验模型中研究了全身和局部血管收缩剂对局部递送标记物递送的影响。与对照组相比,全身给予血管紧张素II导致正常肝脏中标记物显著潴留,但肿瘤中未出现这种情况。局部给予血管紧张素II和去氧肾上腺素导致肿瘤中标记物的潴留明显多于肝脏,注射后1分钟标记物的总体潴留增加了4倍。注射90分钟后,与对照动物相比,标记物仍有显著潴留。肝动脉血管收缩剂的局部递送增加了标记物的递送,并且可能增加化疗药物向肝肿瘤的递送。