Department of Biomedical Engineering, Washington University, St. Louis, Missouri 63130, USA.
Langmuir. 2010 Jun 15;26(12):10005-12. doi: 10.1021/la100127w.
This article describes a simple method for controlling the assembly of gold nanoparticles (Au NPs) into chainlike structures with tunable lengths and interparticle separations. The chainlike assemblies were induced to form by adding HS(CH(2))(n)COOH (n = 2, 10, and 15) into a suspension of Au NPs in a mixture of ethanol and water (98:2 by volume). The number of Au NPs in the chainlike assemblies could be altered by varying the concentration of the thiol while the interparticle distance between Au NPs in the chain could be adjusted by using thiols of different chain lengths. The chainlike assemblies of Au NPs were structurally unstable during storage and purification. We solved this problem by fixing the chainlike assemblies with silica coating via the Stober method or by encapsulating them inside gelatin microspheres with the use of a fluidic device. After fixing, the chainlike assemblies of Au NPs could be preserved for a long period of time, during which their characteristic optical properties remained unchanged.
本文描述了一种简单的方法，可将金纳米粒子（Au NPs）组装成具有可调长度和粒子间间隔的链式结构。通过向 Au NPs 在乙醇和水（体积比为 98:2）混合物中的悬浮液中添加 HS(CH(2))(n)COOH（n = 2、10 和 15），诱导形成链状组装体。通过改变巯基的浓度可以改变链状组装体中 Au NPs 的数量，而通过使用不同链长的硫醇可以调整 Au NPs 之间的粒子间距离。在储存和纯化过程中，Au NPs 的链状组装体结构不稳定。我们通过使用 Stober 方法用硅涂层固定链状组装体或使用流体制备装置将它们封装在明胶微球内来解决此问题。固定后，Au NPs 的链状组装体可以长时间保存，在此期间其特征光学性质保持不变。
