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Antibody-catalyzed degradation of cocaine.
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Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase.
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Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion.
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Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats.
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Catalytic Antibody Blunts Carfentanil-Induced Respiratory Depression.
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Cocaine vaccine dAd5GNE protects against moderate daily and high-dose "binge" cocaine use.
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Reaction Pathway for Cocaine Hydrolase-Catalyzed Hydrolysis of (+)-Cocaine.
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Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase.
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Plasma butyrylcholinesterase regulates ghrelin to control aggression.
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Vaccines against drugs of abuse: where are we now?
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The future potential for cocaine vaccines.
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Vaccine for cocaine dependence: a randomized double-blind placebo-controlled efficacy trial.
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Drug users' adherence to a 6-month vaccination protocol: effects of motivational incentives.
Drug Alcohol Depend. 2010 Feb 1;107(1):76-9. doi: 10.1016/j.drugalcdep.2009.09.006. Epub 2009 Oct 13.
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Lasting reduction of cocaine action in neostriatum--a hydrolase gene therapy approach.
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Vaccines for cocaine abuse.
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Substance abuse vaccines.
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Most efficient cocaine hydrolase designed by virtual screening of transition states.
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An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties.
Chem Biol Interact. 2008 Sep 25;175(1-3):83-7. doi: 10.1016/j.cbi.2008.04.024. Epub 2008 May 1.
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A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats.
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Bioscavenger for protection from toxicity of organophosphorus compounds.
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