唾液腺上皮细胞：基因治疗中一个不起眼的靶标。
Salivary epithelial cells: an unassuming target site for gene therapeutics.
机构信息
Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-1190, USA.
出版信息
Int J Biochem Cell Biol. 2010 Jun;42(6):773-7. doi: 10.1016/j.biocel.2010.02.012. Epub 2010 Feb 26.
Salivary glands are classical exocrine glands whose external secretions result in the production of saliva. However, in addition to the secretion of exocrine proteins, salivary epithelial cells are also capable of secreting proteins internally, into the bloodstream. This brief review examines the potential for using salivary epithelial cells as a target site for in situ gene transfer, with an ultimate goal of producing therapeutic proteins for treating both systemic and upper gastrointestinal tract disorders. The review discusses the protein secretory pathways reported to be present in salivary epithelial cells, the viral gene transfer vectors shown useful for transducing these cells, model transgenic secretory proteins examined, and some clinical conditions that might benefit from such salivary gland gene transfer.
唾液腺是经典的外分泌腺，其外分泌产物导致唾液的产生。然而，除了外分泌蛋白的分泌外，唾液腺上皮细胞还能够将蛋白质内部分泌到血液中。这篇简短的综述探讨了将唾液腺上皮细胞作为原位基因转移靶位的可能性，其最终目标是产生治疗全身性和上消化道疾病的治疗性蛋白质。该综述讨论了报道存在于唾液腺上皮细胞中的蛋白质分泌途径、已证明对这些细胞有用的病毒基因转移载体、检查过的模型转基因分泌蛋白，以及可能受益于这种唾液腺基因转移的一些临床情况。
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