美国食品药品监督管理局发布黑框警告后，夏威夷儿童和青少年抗抑郁药物处方趋势的变化。
Changes in antidepressant medications prescribing trends in children and adolescents in Hawai'i following the FDA black box warning.
作者信息
Hassanin Hanan, Harbi Al, Saif Abdullah, Davis Jim, Easa David, Harrigan Rosanne
机构信息
Uniformed Services University of the Health Sciences, Forest Hills, NY 11375, USA.
出版信息
Hawaii Med J. 2010 Jan;69(1):17-9.
OBJECTIVES
To study prescribing trends for antidepressants in Hawai'i following the FDA black box warning regarding the possible risk of suicide in children and adolescents. We also explored relationships between changes in prescribing trends and patient and provider characteristics.
STUDY DESIGN
Analysis of an existing insurance data set of prescriptions to children and adolescents within the State of Hawai'i.
STUDY POPULATION
Children and adolescents under 18-years-old insured through the largest (>60%) third-party insurance company in the state.
RESULTS
Our results showed variations in changes in prescribing trends for different selective serotonin reuptake inhibitors (SSRIs) following the FDA black box warning. SSRIs with more evidence-based research supporting their safety and efficacy were least affected as were those that were less implicated by the FDA analysis of the possible link between SSRIs and Suicidality. Trends were apparent for all age groups examined and for both females and males.
CONCLUSIONS
Changes in prescribing patterns of psychiatric medications for children and adolescents in Hawai'i were identified. Differing patterns have evolved since 2003 following the series of concerns raised regarding SSRIs and suicidality in children and adolescents.
目的
在食品药品监督管理局（FDA）针对儿童和青少年使用抗抑郁药可能存在自杀风险发布黑框警告之后，研究夏威夷州抗抑郁药的处方开具趋势。我们还探讨了处方开具趋势变化与患者及医疗服务提供者特征之间的关系。
研究设计
对夏威夷州儿童和青少年现有保险处方数据集进行分析。
研究对象
通过该州最大（>60%）的第三方保险公司参保的18岁以下儿童和青少年。
结果
我们的结果显示，在FDA发布黑框警告之后，不同选择性5-羟色胺再摄取抑制剂（SSRI）的处方开具趋势变化存在差异。有更多循证研究支持其安全性和有效性的SSRI受影响最小，FDA对SSRI与自杀倾向之间可能联系的分析中涉及较少的那些药物也是如此。在所有接受检查的年龄组以及男性和女性中均呈现出明显趋势。
结论
确定了夏威夷州儿童和青少年精神科药物处方开具模式的变化。自2003年以来，针对儿童和青少年使用SSRI及自杀倾向引发一系列担忧之后，出现了不同的模式。
Zotero 插件