Misra V, Hudson J B
Arch Virol. 1977;55(4):305-13. doi: 10.1007/BF01315052.
A line of murine cytomegalovirus (MCMV)-resistant cells was derived from mouse embryo cultures. The virus penetrated the nuclei of these resistant cells efficiently and a small amount of viral gene transcription occurred, although no viral DNA synthesis was detected. Synthesis of cellular DNA, RNA and protein continued unabated, and the infected cells grew at the same rate as uninfected cells. The block in virus replication in these cells appears to be between early transcription and viral DNA synthesis.
一株抗小鼠巨细胞病毒(MCMV)的细胞系源自小鼠胚胎培养物。该病毒能有效地穿透这些抗性细胞的细胞核,并且发生了少量的病毒基因转录,尽管未检测到病毒DNA合成。细胞DNA、RNA和蛋白质的合成持续进行且未受影响,受感染细胞的生长速度与未感染细胞相同。这些细胞中病毒复制的阻滞似乎发生在早期转录和病毒DNA合成之间。