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暴食、懒惰与代谢综合征：通向脂毒性的路径。

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity.

机构信息

Department of Internal Medicine, University of Texas Southwestern Medical Center, Touchstone Center for Diabetes Research, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

出版信息

Trends Endocrinol Metab. 2010 Jun;21(6):345-52. doi: 10.1016/j.tem.2010.01.009. Epub 2010 Mar 10.

DOI:10.1016/j.tem.2010.01.009
PMID:20223680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2880185/
Abstract

Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin.

摘要

一度被认为是罪恶的天谴，肥胖（代谢综合征）的合并症如今归因于肥胖引起的代谢缺陷。在这里，我们提出肥胖和高瘦素血症可保护不耐脂的非脂肪组织免受持续热量过剩时的脂毒性脂质溢出。代谢综合征归因于与年龄相关的抗瘦素脂毒性保护作用的抵抗引起的脂毒性。

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本文引用的文献

[1]
The road from discovery to clinic: adiponectin as a biomarker of metabolic status.

Clin Pharmacol Ther. 2009-12

[2]
Adipose tissue collagen VI in obesity.

J Clin Endocrinol Metab. 2009-10-16

[3]
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J Clin Endocrinol Metab. 2009-10

[4]
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.

J Clin Invest. 2009-9

[5]
Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue.

Mol Cell Biol. 2009-8

[6]
Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies.

Trends Pharmacol Sci. 2009-5

[7]
The role of transcriptional regulators in central control of appetite and body weight.

Nat Clin Pract Endocrinol Metab. 2009-3

[8]
Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI.

Mol Cell Biol. 2009-3

[9]
The adipocyte as an endocrine cell.

Endocrinol Metab Clin North Am. 2008-9

[10]
Variable contributions of fat content and distribution to metabolic syndrome risk factors.

Metab Syndr Relat Disord. 2008-12

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