利用动物模型了解哮喘。
Understanding asthma using animal models.
机构信息
Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO, USA.
出版信息
Allergy Asthma Immunol Res. 2009 Oct;1(1):10-8. doi: 10.4168/aair.2009.1.1.10. Epub 2009 Sep 25.
Abstract
Asthma is a complex syndrome with many clinical phenotypes in children and adults. Despite the rapidly increasing prevalence, clinical investigation and epidemiological studies of asthma, the successful introduction of new drugs has been limited due to the different disease phenotypes and ethical issues. Mouse models of asthma replicate many of the features of human asthma, including airway hyperreactivity, and airway inflammation. Therefore, examination of disease mechanisms in mice has been used to elucidate asthma pathology and to identify and evaluate new therapeutic agents. In this article, we discuss the various animal models of asthma with a focus on mouse strains, allergens, protocols, and outcome measurements.
摘要
哮喘是一种复杂的综合征，在儿童和成人中具有许多临床表型。尽管哮喘的患病率迅速增加，但由于疾病表型和伦理问题的不同，临床研究和流行病学研究的进展有限，新药物的成功引入受到限制。哮喘的小鼠模型复制了许多人类哮喘的特征，包括气道高反应性和气道炎症。因此，在小鼠中检查疾病机制已被用于阐明哮喘病理学，并识别和评估新的治疗剂。在本文中，我们讨论了各种哮喘的动物模型，重点是小鼠品系、过敏原、方案和结果测量。
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