Alfa Institute of Biomedical Sciences (AIBS), 9 Neapoleos Street, 151 23 Marousi, Athens, Greece.
Int J Antimicrob Agents. 2010 May;35(5):497-9. doi: 10.1016/j.ijantimicag.2010.01.010. Epub 2010 Mar 11.
We aimed to evaluate the antimicrobial activity of fosfomycin against Gram-positive non-urinary isolates collected at the microbiological laboratory of the University Hospital of Heraklion, Crete, Greece, in 2008. Susceptibility testing was performed by the disk diffusion method for a total of 1846 isolates; 1275 isolates (69.1%) were susceptible to fosfomycin. Specifically, 416/419 Staphylococcus aureus (99.3%) [including 129/130 meticillin-resistant S. aureus (MRSA) isolates] and 745/961 coagulase-negative staphylococci (77.5%) were susceptible to fosfomycin. Among 42 Streptococcus pneumoniae, 64 Streptococcus pyogenes and 93 other streptococcal isolates, 61.9%, 40.6% and 48.4%, respectively, were susceptible to fosfomycin. Fosfomycin was inactive against the 166 enterococcal isolates tested. This old antibiotic may deserve consideration for further studies and use in clinical practice, especially for S. aureus (including MRSA) infections.
我们旨在评估磷霉素对希腊克里特岛伊拉克利翁大学医院微生物实验室 2008 年收集的革兰氏阳性非尿分离株的抗菌活性。总共对 1846 株分离株进行了药敏试验，其中 1275 株（69.1%）对磷霉素敏感。具体来说，419 株金黄色葡萄球菌（99.3%）[包括 130 株耐甲氧西林金黄色葡萄球菌（MRSA）分离株中的 129 株]和 961 株凝固酶阴性葡萄球菌（77.5%）对磷霉素敏感。42 株肺炎链球菌、64 株化脓性链球菌和 93 株其他链球菌分离株中，分别有 61.9%、40.6%和 48.4%对磷霉素敏感。166 株肠球菌分离株对磷霉素无活性。这种老抗生素可能值得进一步研究和临床应用，特别是对金黄色葡萄球菌（包括 MRSA）感染。
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