Monash Centre for Occupational and Environmental Health, Department of Epidemiology and Preventive Medicine, Monash University, The Alfred Hospital, CommercialRoad, Melbourne, Victoria 3004, Australia.
Ann Epidemiol. 2010 Apr;20(4):273-80. doi: 10.1016/j.annepidem.2010.01.004.
To determine the rates of mortality and of cancer incidence in a cohort of pesticide-exposed Australian workers.
The study cohort was assembled using records of former government occupational health surveillance programs. The cohort was then linked to the Australian national registries of cancer and mortality and analyzed in comparison with the general Australian population.
Consistent with a healthy worker effect, we found no overall excesses in mortality or incident cancer. Non-injury-related causes of death were less than expected; however, non-intentional poisoning and suicide mortality were significantly elevated. All types of suicide were elevated, and firearm suicide deaths were significantly in excess. The suicides by poisoning were predominantly associated with pesticides, although other published research suggests this pattern is more often associated with developing countries.
This study did not find evidence of a relationship between occupational pesticide exposure and cancer or non-injury-related mortality. However, accidental poisoning and intentional self-harm warrant further investigation.
确定接触农药的澳大利亚工人队列的死亡率和癌症发病率。
该研究队列是使用政府职业健康监测计划的记录组建的。然后，将该队列与澳大利亚国家癌症和死亡率登记册进行了关联，并与澳大利亚普通人群进行了比较分析。
与健康工人效应一致，我们没有发现死亡率或癌症发病率总体过高的情况。非伤害相关死因少于预期；然而，非故意中毒和自杀死亡率显著升高。所有类型的自杀都升高了，枪支自杀死亡明显过多。中毒自杀主要与农药有关，尽管其他已发表的研究表明，这种模式更常见于发展中国家。
本研究没有发现职业性农药暴露与癌症或非伤害相关死亡率之间存在关系的证据。然而，意外中毒和故意自残需要进一步调查。
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