Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain.
Microbes Infect. 2010 Jun;12(6):438-45. doi: 10.1016/j.micinf.2010.03.003. Epub 2010 Mar 12.
Immunological synapses (IS) are emerging as highly organized 3D structures -formed by surface and cytoplasmic signalling and cytoskeletal molecules - that assemble at the zone of contact between a T cell and an antigen presenting cell (APC). The IS control functions that allow APC and T cells modulate the immune response.
免疫突触(IS)作为高度组织化的 3D 结构正在出现,这些结构由表面和细胞质信号以及细胞骨架分子形成,组装在 T 细胞和抗原呈递细胞(APC)之间的接触区域。IS 控制功能允许 APC 和 T 细胞调节免疫反应。