多发性硬化症中 B 细胞 Toll 样受体 9 介导的白细胞介素-10 产生减少。
Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis.
机构信息
Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
出版信息
J Neuroimmunol. 2010 Apr 15;221(1-2):95-100. doi: 10.1016/j.jneuroim.2010.02.012. Epub 2010 Mar 15.
The complexity of the roles of Toll-like receptors (TLRs) is attributable to their ability to promote or suppress autoimmune diseases. Recent studies have demonstrated that B cells regulate autoimmune diseases, including multiple sclerosis (MS), by producing interleukin (IL)-10. By using CpG DNA as a TLR9 agonist, we investigated the immunoregulatory functions of B cell via TLR9 in MS. Our results indicate that TLR9-mediated IL-10 production by B cells was significantly decreased in MS, and this decrease is likely due to decreased TLR9 expression in memory B cells, suggesting a role of TLR9 in immunoregulation in MS.
Toll 样受体 (TLRs) 的作用复杂，因为它们能够促进或抑制自身免疫性疾病。最近的研究表明，B 细胞通过产生白细胞介素 (IL)-10 来调节自身免疫性疾病，包括多发性硬化症 (MS)。通过使用 CpG DNA 作为 TLR9 激动剂，我们研究了 B 细胞通过 TLR9 在 MS 中的免疫调节功能。我们的结果表明，MS 中 B 细胞介导的 TLR9 诱导的 IL-10 产生显著减少，这可能是由于记忆 B 细胞中 TLR9 表达降低所致，提示 TLR9 在 MS 中的免疫调节作用。
Zotero 插件