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[老年住院患者的谵妄。18个月随访]

[Delirium in elderly inpatients. An 18 month follow-up].

作者信息

Vázquez Fernando J, Benchimol Javier, Giunta Diego, Cafferata Carlos, Freixas Antonio, Vallone Marcelo, Andresik Diego, Pollan Javier, Aprile Ana, Lorenzo Jimena, Waisman Gabriel, Camera Luis

机构信息

Servicio de Clínica Médica, Hospital Italiano de Buenos Aires.

出版信息

Medicina (B Aires). 2010;70(1):8-14.

Abstract

Delirium usually hardens care during hospitalization and increases morbidity during hospital stay and after discharge. The objective of this study was to describe the prevalence of delirium in elderly inpatients in a Buenos Aires hospital, its morbidity and mortality during hospital stay and the next 18 month follow-up. Patients aged 70 or older admitted to internal medicine unit between September 2005 and May 2006 were enrolled. Delirium was assessed with the Spanish version of Confusion Assessment Method. Demographic data, cause of admition and length of stay, destination after discharge and mortality were registered. A new evaluation was made 18 months after discharge. We evaluated 194 patients and 74 were excluded. Of the 120 included, 52 (43.3%) presented delirium. We found significant differences between patients with and without delirium in previous placement in nursing home (17.3% vs. 1.5%; p < 0.002), dementia (40.4% vs. 8.8%; p < 0.001), median activity of daily living (5 vs. 6; p < 0.001), length-of-stay (7 vs. 5; p = 0.04) and mortality rate (21.2% vs. 1.5%; p < 0.001). Evaluation 18 months later showed differences between patients with and without delirium in median of activity of daily living (1/6 vs. 5/6), patients living in nursing homes (27.5% vs. 7.9%), estimated survival 35.3% (CI 95%: 24-49%) at day 569 and 49% (CI 95%: 32.9-65.4%) at day 644. The difference between survival curves was statistically significant (p = 0.027). Delirium increases morbidity and mortality during hospital stay. Elderly with delirium are at risk of worsening disability and of becoming dependent after discharge and it is a risk factor for higher mortality during the following months after discharge.

摘要

谵妄通常会使住院期间的护理变得棘手,并增加住院期间及出院后的发病率。本研究的目的是描述布宜诺斯艾利斯一家医院老年住院患者中谵妄的患病率、住院期间的发病率和死亡率以及接下来18个月随访期内的情况。纳入了2005年9月至2006年5月期间入住内科病房的70岁及以上患者。使用西班牙语版的《混乱评估方法》对谵妄进行评估。记录人口统计学数据、入院原因和住院时间、出院去向及死亡率。出院18个月后进行了一次新的评估。我们评估了194例患者,排除了74例。在纳入的120例患者中,52例(43.3%)出现谵妄。我们发现,有谵妄和无谵妄的患者在之前是否入住养老院(17.3%对1.5%;p<0.002)、是否患有痴呆(40.4%对8.8%;p<0.001)、日常生活活动中位数(5对6;p<0.001)、住院时间(7天对5天;p = 0.04)以及死亡率(21.2%对1.5%;p<0.001)方面存在显著差异。18个月后的评估显示,有谵妄和无谵妄的患者在日常生活活动中位数(1/6对5/6)、居住在养老院的患者比例(27.5%对7.9%)、第569天的估计生存率为35.3%(95%CI:24 - 49%)以及第644天的估计生存率为49%(95%CI:32.9 - 65.4%)方面存在差异。生存曲线之间的差异具有统计学意义(p = 0.027)。谵妄会增加住院期间的发病率和死亡率。患有谵妄的老年人在出院后有残疾恶化和依赖他人的风险,并且是出院后接下来几个月死亡率较高的一个风险因素。

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