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细胞质 FABP 超家族的初步研究。

Initial studies of the cytoplasmic FABP superfamily.

机构信息

Department of Biochemistry, School of Medicine, Niigata University, Niigata, Japan.

出版信息

Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(3):220-8. doi: 10.2183/pjab.86.220.

DOI:10.2183/pjab.86.220
PMID:20228622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3417847/
Abstract

Our colleagues and we have determined the complete primary structure of a low molecular weight cytoplasmic FABP (also known as z-protein) that binds to LCFAs with high affinities, obtained from rat liver. At the same time, we were the first to propose that rat FABP1, bovine FABP8 (MP-2), bovine CRBP and rat CRABP constituted a protein superfamily in 1982. Since then, extensive investigation of structures, functions and expressions has been carried out on a whole family of FABPs. Analyses of rat heart FABP; FABP1, FABP3 and alpha(2U)-globulin expressed in rat kidney; discovery of ileal FABP6 (I-15P); and first application of FABP2 as a diagnostic marker also stand out in particular.

摘要

我们的同事和我已经确定了从小鼠肝脏中提取的与 LCFAs 具有高亲和力的低分子量细胞质 FABP（也称为 z 蛋白）的完整一级结构。同时，我们在 1982 年率先提出大鼠 FABP1、牛 FABP8（MP-2）、牛 CRBP 和大鼠 CRABP 构成一个蛋白质超家族。此后，对 FABP 全家族的结构、功能和表达进行了广泛的研究。对大鼠心脏 FABP、大鼠肾脏中表达的 FABP1、FABP3 和α2U-球蛋白、发现回肠 FABP6（I-15P）、以及首次将 FABP2 用作诊断标志物的应用也尤为突出。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/391b/3417847/6170172a79c7/pjab-86-220-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/391b/3417847/605076400fbf/pjab-86-220-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/391b/3417847/40a481429264/pjab-86-220-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/391b/3417847/bbfe0ef7080b/pjab-86-220-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/391b/3417847/c0dda87e2181/pjab-86-220-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/391b/3417847/e0fa60c16282/pjab-86-220-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/391b/3417847/6170172a79c7/pjab-86-220-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/391b/3417847/605076400fbf/pjab-86-220-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/391b/3417847/40a481429264/pjab-86-220-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/391b/3417847/bbfe0ef7080b/pjab-86-220-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/391b/3417847/c0dda87e2181/pjab-86-220-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/391b/3417847/e0fa60c16282/pjab-86-220-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/391b/3417847/6170172a79c7/pjab-86-220-g006.jpg

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